TUDCA Supplements | Buy Tauroursodeoxycholic Acid 500mg | Charava

TUDCA (Tauroursodeoxycholic Acid)

TUDCA is one of the most thoroughly researched bile acids in longevity and liver science. Charava's TUDCA delivers 500mg of pharmaceutical-grade tauroursodeoxycholic acid per capsule, vegan, GMP-certified, and free from fillers. Whether you're supporting liver health, cellular resilience, or a broader longevity stack, this is where to start.

What is TUDCA?

TUDCA stands for tauroursodeoxycholic acid, a water-soluble bile acid naturally synthesised in the liver from UDCA (ursodeoxycholic acid) and the amino acid taurine. Small amounts are produced endogenously, but therapeutic and longevity-focused supplementation typically requires doses of 250 to 1,000mg per day, well beyond what the body produces on its own.

Unlike standard UDCA, a prescription medication used for liver conditions, TUDCA's taurine conjugation makes it significantly more hydrophilic and bioavailable. This improved solubility means it is better absorbed, more effective at low doses, and gentler on the gut. TUDCA is the preferred form for supplementation.

What Does TUDCA Do?

TUDCA acts on several interconnected biological pathways that are central to liver health, cellular function, and healthy ageing.

Liver protection. TUDCA promotes healthy bile flow and protects hepatocytes (liver cells) from damage caused by toxic bile acid accumulation. It has been used clinically for cholestasis, a condition where bile flow from the liver is impaired, and has shown significant reductions in liver enzymes (ALT and AST) in controlled trials.

Endoplasmic reticulum (ER) stress relief. The endoplasmic reticulum is responsible for folding proteins within cells. When proteins misfold due to toxins, metabolic stress, or ageing, ER stress occurs, driving inflammation, insulin resistance, and cell death. TUDCA acts as a chemical chaperone, stabilising proteins and dramatically reducing ER stress. This is one of the most significant mechanisms underpinning its effects on metabolic and neurological health.

Mitochondrial support. TUDCA preserves mitochondrial membrane integrity and inhibits the release of cytochrome c, a key trigger of cell death (apoptosis). Healthy mitochondria are fundamental to energy production, athletic performance, and cellular longevity.

Neuroprotection. TUDCA crosses the blood-brain barrier and has been studied for its effects on dopaminergic neuron survival, amyloid-beta toxicity, and neuroinflammation. Research has explored its potential in models of Parkinson's disease, Alzheimer's disease, ALS, and stroke.

Metabolic health. Landmark research published in Science demonstrated that TUDCA supplementation improved insulin sensitivity in obese humans, an effect attributed to its ability to reduce ER stress in both liver and muscle tissue. This makes TUDCA relevant not just for liver health but for blood sugar regulation and weight management.

Anti-inflammatory and antioxidant activity. TUDCA suppresses NF-κB signalling, a master regulator of inflammatory gene expression, while scavenging reactive oxygen species (ROS). This dual action helps reduce chronic low-grade inflammation, one of the primary drivers of age-related decline.

Who Uses TUDCA?

TUDCA is used across a wide range of health and performance goals. People supporting liver health tend to use it, particularly those on high-protein diets, oral medications, or who consume alcohol regularly. Athletes and bodybuilders use it to maintain liver resilience during training cycles and supplementation. Longevity enthusiasts stack it with NMN, NAD+, resveratrol, and other longevity compounds. It's also popular among those with elevated liver enzymes as a complement to dietary and lifestyle interventions (always in consultation with a GP), and anyone interested in cellular health given TUDCA's broad cytoprotective and anti-inflammatory properties.

TUDCA Dosage: How Much Should You Take?

The doses used in clinical studies range from 250mg to 1,750mg per day, depending on the condition being studied. For general liver support and longevity purposes, 500mg per day is the most widely used and well-tolerated dose, which is exactly what each Charava capsule provides. Take one capsule in the morning, with or before a meal.

TUDCA vs UDCA: What's the Difference?

UDCA (ursodeoxycholic acid) is the parent compound, a prescription-only medication used in clinical practice for primary biliary cholangitis and gallstones. TUDCA is its taurine-conjugated derivative, offering superior water solubility, better gut absorption, and more potent cytoprotective activity in research settings. For supplementation, TUDCA is the superior choice.

Why Buy TUDCA from Charava?

Not all TUDCA supplements deliver what they promise. Each capsule contains 500mg of pharmaceutical-grade TUDCA, a full, research-consistent dose. Manufacturing is GMP-certified and independently audited to ISO 9001:2015 standards, with Certificates of Analysis available for full transparency on purity and potency. The formula is 100% vegan, using a plant-based hypromellose capsule with no animal-derived ingredients, no fillers, no binders, and no artificial additives. Charava also offers UK-based customer support and a subscribe and save option of up to 20%, with free gifts worth up to £141 on qualifying subscription orders.

Frequently Asked Questions

Is TUDCA safe? TUDCA has an extensive clinical safety profile and is generally well tolerated at doses up to 1,750mg per day in studies. The most commonly reported side effect at high doses is mild digestive discomfort. As with any supplement, consult your healthcare professional before use, especially if you are taking prescription medication or have a diagnosed liver condition.

How long does TUDCA take to work? Most people notice improvements in digestion and energy within one to two weeks. For liver enzyme markers and deeper cellular effects, measurable changes are typically seen after four to eight weeks of consistent daily use.

Can I take TUDCA with other supplements? TUDCA combines well with NMN, NAD+, CoQ10, berberine, and other longevity and metabolic support supplements. There are no well-established negative interactions with common supplements. If you are on prescription medication, speak with your GP before stacking.

Do I need to cycle TUDCA? No cycling is required. TUDCA is a naturally occurring bile acid and can be taken continuously. Many users take it as part of a daily long-term stack.

Is Charava's TUDCA vegan? Yes. The capsule shell is made from hypromellose, a plant-derived alternative to standard gelatin capsules. The formula contains no animal-derived ingredients and no GMOs.

What is the difference between TUDCA and ox bile supplements? Ox bile supplements contain a broad mixture of bile acids, of which TUDCA is only a small component. Supplementing with pure TUDCA gives you a precise, concentrated dose of the specific compound backed by the majority of clinical research.